任明光

个人简历：

2002.09-2006.07 聊城大学 化学与化工学院  本科

2006.09-2011.11  中国科学技术大学 化学与材料科学学院  博士

2011.12-2014.06 康龙化成（北京）新药技术有限公司

2014. 06-2016.07济南大学光功能材料与成像研究院讲师

2016.08-2019.10济南大学光功能材料与成像研究院副教授

2020. 01-至今 齐鲁工业大学 生物基材料与绿色造纸国家重点实验室

研究方向：

小分子荧光染料的设计、合成与生物成像应用研究、壳聚糖和纤维素为基质的高分子荧光探针的设计与应用研究。

主持项目：

1. 国家自然科学基金青年项目、批准号：21502067、基于跨键能量传递机理构建一氧化氮双光子比率荧光探针及其生物成像研究、2016/01-2018/12、25万、主持。

2. 山东省自然科学基金培养基金项目、ZR2014BP001、一氧化氮双光子荧光探针的构建与生物成像研究、2015/01-2016/12、5万元、主持。

发表文章：

共发表SCI论文28篇，英文专章2篇。其中第一作者论文15篇，其中一区论文7篇，二区论文4篇，三区论文4篇。其中影响因子＞10的有1篇，＞5的11篇。文章总引用次数将近700余次，其中单篇引用超过80的两篇，单篇引用超过40的有6篇。指导研究生发表SCI论文13篇。

1. Mingguang Ren,Zihong Li, Beibei Deng, Li Wang, Weiying Lin. Single Fluorescent Probe Separately and Continuously Visualize H2S and HClO in Lysosomes with Different Fluorescence Signals.Anal. Chem., 2019, 91, 2932-2938. (一区SCI：IF=6.785)

2. Mingguang Ren, Zihong Li, Jing Nie, Li Wang, Weiying Lin*, A Photocaged Fluorescent Probe for Imaging Hypochlorous Acid in Lysosome,Chem. Commun.,2018,54, 9238-9241. (一区SCI：IF=5.996)

3. Mingguang Ren, Kai Zhou, Longwei He, Weiying Lin* Mitochondria and Lysosome-Targetable Fluorescent Probes for HOCl: Recent Advances and Perspectives,J. Mater. Chem. B, 2018, 6, 1716-1733. (二区SCI：IF=5.344)

4. Mingguang Ren, Kai Zhou, Li Wang, Keyin Liu, Weiying Lin* Construction of a ratiometric two-photon fluorescent probe to monitor the changes of mitochondrial viscosity,Sensor. Actuat. B: Chem.,2018,262, 452-459. (一区SCI；IF=7.100)

5. Mingguang. Ren, Baoli.Dong, Weiying. Lin*Fluorescent probes for HNO detection. The Chemistry and Biology of Nitroxyl (HNO) (Editors: Fabio Doctorovich, Patrick Farmer and Marcelo Martí, Elsevier, New York, NY, USA.).  2017, Chapter 10,207-224.(英文专章)

6. Mingguang. Ren, Beibei. Deng, Xiuqi. Kong, Yonghe Tang, Weiying. Lin* Preparation of a Two-photon Fluorescent Probe for Imaging H2O2 in Lysosomes in Living Cells and Tissues, "Lysosomes: Methods and Protocols", "Methods in Molecular Biology"(Editors: Karin Öllinger and Hanna Appelqvist), Springer,2017,129-139. (英文专章)

7. Mingguang. Ren, Beibei. Deng, Kai. Zhou, Jian.-Yong. Wang, Xiuqi. Kong and Weiying. Lin*, A Targetable Fluorescent Probe for Imaging Exogenous and Intracellular Formed Nitroxyl at Mitochondria in Living Cells,J. Mater. Chem. B,2017,5, 1954-1961. (二区SCI：IF=5.344)

8. Mingguang. Ren, Beibei. Deng, Kai. Zhou, Xiuqi. Kong, Jian-Yong.Wang and Weiying. Lin*, A Single fluorescent probe for Dual-imaging Viscosity and H2O2 in Mitochondria with Different Fluorescence Signals in Living Cells,Anal. Chem.,2017, 89, 552-555. (一区SCI IF=6.785)

9. Mingguang. Ren, Jing. Nie, Beibei. Deng, Kai. Zhou, Jian.-Yong. Wang, Weiying. Lin*, A Fluorescent Probe for Ratiometric Imaging Exogenous and Intracellular Formed Hypochlorous Acid in Lysosomes,New J. Chem.,2017, 41, 5259-5262.  (三区SCI；IF=3.288)

10. Mingguang. Ren, Beibei. Deng, Kai. Zhou, Xiuqi. Kong, Jian-Yong.Wang, Gaoping Xue and Weiying. Lin*, A Lysosome-targeted and Ratiometric Fluorescent Probe for Imaging Exogenous and Endogenous Hypochlorous Acid in Living Cells,J. Mater. Chem. B,2016,4, 4739-4745. (二区SCI；IF=5.344)

11. Mingguang. Ren, Beibei. Deng, Xiuqi. Kong, Kai. Zhou, Keyin Liu, Gaoping Xue and Weiying. Lin*, A TICT-based fluorescent probe for rapid and specific detection of hydrogen sulfide and its bio-imaging applications,Chem. Commun., 2016,52, 6415-6418. (一区SCIIF=5.996)

12. Mingguang. Ren, Beibei. Deng, Jian-Yong. Wang, Xiuqi. Kong, Zan-Rong. Liu, Kai. Zhou, Liongwei. He and Weiying. Lin*, A fast responsive two-photon fluorescent probe for imaging H2O2 in lysosomes with a large turn-on fluorescence signal.Biosens. Bioelectron.,2016,79, 237-243. (一区SCI；IF=10.257)

13. Mingguang Ren, Beibei Deng, Jian-Yong Wang, Zhan-Rong Liu, Weiying Lin* A dual-emission fluorescence-enhanced probe for imaging copper(ii) ions in lysosomes,J. Mater. Chem. B,2015,3, 6746-6752. (二区SCI；IF=5.344)

14. Mingguang Ren, Mao Mao, Qin-Hua Song* The equilibra and conversions between three excited state: the LE state and two charge transfer states, in twised pyrene-substituted tridarylborates.Chem. Commun. 2012.48, 2970-2972. (一区SCI；IF=5.996)

15. Mingguang Ren, Hui-Jun Guo, Fei Qi, Qin-Hua Song* Fluorescent pyrene-centered starburst oligocarbazoles with excellent thermal and electrochemical stabilities.Org. Biomol. Chem.2011, 9, 6913-6916. (三区SCI IF=3.412)

16. Mingguang Ren, Nai-Min Bi, Mao, Mao, Xue.-You Duan, Qin-Hua Song* Hydrogen peroxide synthesis via direct photoreduction of 2-ethylanthraquinone in aerated solutions, J. Photochem. Photobiol. A:Chem.2011,217, 164-168. (三区SCI；IF=3.306)

17. Mingguang Ren, Nai-Min Bi, Mao Mao, Qin-Hua Song* 2-(1-Hydroxyethyl)-anthraquinone as a photolabile protecting group for carboxylic acids, J. Photochem. Photobiol. A:Chem. 2009,204, 13-18.  (三区SCI；IF=3.306)

18. Lixuan Dai,Mingguang Ren, Zihong Li, Li Wang, Weiying Lin*, A targetable fluorescent probe for imaging of mitochondria viscosity in living cells,Anal. Methods, 2019, 11, 4561-4565. (三区SCI)

19. Zihong Li,Mingguang Ren, Li Wang, Kai Zhou, Weiying Lin*, An ethyl cyanoacetate based turn-on fluorescent probe for hydrazine and its bio-imaging and environmental applications,Anal. Methods,2018,10, 4016-4019. (三区SCI)

20. Zihong Li,Mingguang Ren, Li Wang, Lixuan Dai, Weiying Lin*, Development of a two-photon fluorescent probe for the selective detection of β-galactosidase in living cells and tissues，J. Mater. Chem. B,2019,21, 3431-3437. (二区SCI). 

21. Zihong Li,Mingguang Ren, Li Wang, Lixuan Dai, Weiying Lin*, Development of ared-emissive two-photon fluorescent probe for sensitive detection of beta-galactosidase inliving cells andin vivo. Sensor. Actuat. B: Chem.,2020，307，127643 (一区SCI)

22. Li Wang,Mingguang Ren, Zihong Li, Lixuan Dai and Weiying Lin*. A novel high selective fluorescent probe for imaging of cysteine both in living cells and zebrafish.Anal. Methods,2019, 11, 4323-4327. (三区SCI)

23. Li Wang,Mingguang Ren, Zihong Li, Lixuan Dai and Weiying Lin*. A ratiometric two-photon fluorescent probe for the rapid detection of HClO in living systems.Anal. Methods,2019,11, 1580-1584. (三区SCI)

24. Li Wang,Mingguang Ren, Zihong Li, Lixuan Dai, Weiying Lin*. Development of a FRET-based ratiometric fluorescent probe to monitor the changes of palladium(II) in aqueous solution and living cells.New J. Chem. 2018,43, 552-555. (三区SCI)

25. Kai Zhou,Mingguang Ren, Li Wang, Zihong Li, Weiying Lin * Preparation of a two-photon fluorescent probe with a large turn-on signal for imaging hypochlorous acid in living tissues.Anal. Methods. 2018, 10, 2546-2550.  (三区SCI)

26. Kai Zhou,Mingguang Ren, Li Wang, Zihong Li, Weiying Lin * A targetable fluorescent probe for real-time monitoring of fluoride ions in mitochondria.Spectrochim. Acta. A,2018,204, 777-782. (二区SCI) 7

27. Kai. Zhou,Mingguang. Ren, Beibei. Deng , Weiying Lin* Development of a viscosity sensitive fluorescent probe for real-time monitoring of mitochondria viscosity,New J. Chem.,2017,41, 11507-11511. (三区SCI) 16

28. Beibei. Deng,Mingguang. Ren, Xiuqi. Kong, Kai. Zhou, Weiying. Lin*Development of an enhanced turn-on fluorescent HOCl probe with a large Stokes shift and its use for imaging HOCl in cells and zebrafish, Sensor. Actuat. B: Chem.,2018, 255,963-969. (一区SCI) 33

29. Beibei. Deng,Mingguang. Ren, Jian-Yong. Wang, Kai. Zhou, Weiying. Lin* A Mitochondrial-Targeted Two-Photon Fluorescent Probe for Imaging Hydrogen Sulfide in the Living Cells and Mouse Liver Tissues,Sensor. Actuat. B: Chem.,2017,248, 50-56. (IF = 5.401). (一区SCI) 21

30. Beibei. Deng,Mingguang. Ren, Xiuqi. Kong, Kai. Zhou, Weiying. Lin* An ESIPT based fluorescent probe for imaging hydrogen sulfide with a large turn-on fluorescence signal,RSC Advances,2016,6, 62406-62410. (三区SCI) 12

申请专利：

(1) 任明光，孔凡功，刘克印，王守娟; 一种可以对癌细胞内线粒体粘度进行成像的荧光探针、制备方法与应用; 申请号：201911265894 ；申请日期：2019-12-11.

(2) 任明光，孔凡功，刘克印，王守娟; 一种双检测荧光探针、制备方法及其在检测硫化氢和铜离子中的应用；申请号：201911266623  ；申请日期：2019-12-11.

(3) 林伟英，任明光，邓贝贝;一种二价铜离子荧光探针及其制备方法和应用; 专利号：ZL 201510235578.X；授权日期：2016-08-24。

(4) 林伟英，任明光，邓贝贝；一种硫化氢分子荧光探针及其制备方法和应用；专利号：ZL 201510239407.4；授权日期：2016-09-28

(5) 林伟英，任明光，邓贝贝； 一种荧光探针在过氧化氢分子检测中的应用；专利号：ZL 201510307821.4；授权日：2017-12-12。申请日：2015-06-08

(6) 林伟英， 任明光， 邓贝贝， 周凯，王建勇，刘展榕；一种溶酶体靶向次氯酸分子荧光探针制备方法与细胞成像应用; 专利号：ZL 201510565576.7；授权日：2017-03-29 。

(7) 林伟英，任明光，邓贝贝，周凯；一种线粒体靶向的亚硝酰氢分子荧光探针及其制备方法和应用；专利号：ZL 201610155887.0授权日：2018-02-13。申请日: 2016-03-18。

(8) 林伟英， 任明光， 邓贝贝;一种荧光增强型硫化氢分子荧光探针及其制备方法和应用;申请号：201610264719.5;申请日:2016-04-28。

(9) 林伟英，任明光，邓贝贝，周凯；一种同时或分别检测细胞溶酶体内硫化氢和次氯酸的荧光探针及其制备方法和应用;专利授权号：ZL 201610263094.0授权日：2018-03-27。

(10) 林伟英，任明光，邓贝贝， 周凯;一种线粒体靶向过氧化氢分子荧光探针及其制备方法和应用;申请号：201610647801.6; 申请日: 2016-08-10。

(11) 林伟英，任明光，周凯，邓贝贝;一种具有线粒体靶向和双光子性质的硫化氢分子荧光探针及其制备方法和应用；申请号：201610647827.0；申请日:2016-08-10。

(12) 林伟英，任明光，邓贝贝;一种线粒体靶向的粘度荧光探针制备方法与细胞成像应用; 申请号：201611167005.9；申请日:2016-12-16。

(13) 林伟英， 任明光， 聂景， 邓贝贝;一种溶酶体靶向次氯酸比率荧光探针制备方法与细胞成像应用；申请号：201710159459.X;申请日:2017-03-17。

(14)  林伟英,任明光，邓贝贝，周凯；一种溶酶体靶向光敏性次氯酸荧光探针制备方法与细胞成像应用；申请号：201710159459.X; 申请日: 2017-03-17

(15)  林伟英，任明光，邓贝贝；一种次氯酸荧光探针及其制备方法和应用；申请号：201710219195.2；申请日：2017-04-06。

(16) 林伟英，任明光，周凯，邓贝贝；线粒体靶向测定粘度的荧光探针及其制备方法和应用；申请号：201710291844.X；申请日：2017-04-28。

(17) 林伟英，任明光，周凯，邓贝贝；一种线粒体靶向氟离子荧光探针制备方法与细胞成像应用；申请号： 107445946A；申请日：2017-08-21。